The Manyeleti Game Reserve is a 23,000-hectare private wildlife reserve located in Mpumalanga, South Africa. It is situated between the Timbavati and Sabi Sands Game Reserves, forming part of the Greater Kruger National Park. The reserve is named after the Manyeleti River, which flows through it. It is home to the Big Five (lion, leopard, elephant, rhinoceros, and Cape buffalo) as well as a diverse range of birdlife, including over 300 species.